منابع مشابه
Biosynthetic Studies of A2E, a Major Fluorophore of RPE Lipofuscin
∗ This work was supported by the National Institutes of Health Grants 34509 (KN) and EY12951 (JRS), the Charina Foundation (JRS), the Macula Vision Research Foundation (JRS) and unrestricted funds from Research to Prevent Blindness. JRS is a recipient of a Research to Prevent Blindness Lew R. Wasserman Merit Award. The costs of publication of this article were defrayed in part by the payment of...
متن کاملThe lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.
Daily phagocytosis of spent photoreceptor outer segments is a critical maintenance function performed by the retinal pigment epithelium (RPE) to preserve vision. Aging RPE accumulates lipofuscin, which includes N-retinylidene-N-retinylethanolamine (A2E) as the major autofluorescent component. We studied the effect of physiological levels of A2E in RPE cultures on their ability to phagocytose ou...
متن کاملRpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.
There is a growing body of evidence that the nondegradable fluorophores that accumulate as the lipofuscin of retinal pigment epithelium (RPE) are involved in mechanisms leading to the degeneration of RPE in macular degeneration. Most of the constituents of RPE lipofuscin are inadvertent products of the retinoid visual cycle, the enzymatic pathway by which the 11-cis-retinal chromophore of rhodo...
متن کاملComplement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium.
Recent studies have implicated local inflammation and activation of complement amongst the processes involved in the pathogenesis of age-related macular degeneration (AMD). Several lines of investigation also indicate that bis-retinoid pigments, such as A2E, that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells, contribute to the disease process. In an investigation of a poten...
متن کاملImmunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells.
The autofluorescent lipofuscin pigment A2E accumulates in retinal pigment epithelial cells with age and is particularly abundant in some retinal disorders. To generate a polyclonal antibody that recognizes this pyridinium bisretinoid molecule, we immunized rabbits with bovine serum albumin (BSA) conjugates in which the protein was linked to the A2E molecule via its pyridinium ethanolamine moiet...
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ژورنال
عنوان ژورنال: Photochemistry and Photobiology
سال: 2007
ISSN: 0031-8655,1751-1097
DOI: 10.1111/j.1751-1097.2004.tb00002.x